Main Campus is the heart of Dilla University, hosting administrative offices, lecture halls, libraries, and laboratories. It serves as a hub for academic and social activities, providing a vibrant atmosphere for students and faculty.

The Main Campus is also dedicated to engineering and technology disciplines, featuring state-of-the-art laboratories, workshops, and classrooms. It fosters innovation and practical skills development among students pursuing engineering degrees.

Key institutions located here include:

• College of Engineering and Technology
• College of Social Sciences and Humanities
• School of Law
• Institute of Education and Behavioral Science